HomeMedicine & BiophysicsDiabetic Neuropathy: Length-Dependent Nerve Conduction Loss

Diabetic Neuropathy: Length-Dependent Nerve Conduction Loss (2D)

Interactive 2D model of a peripheral nerve fibre from spinal cord to toe: adjust chronic glycemic control and disease duration and watch length-dependent 'dying-back' demyelination and axonal loss slow, then block, saltatory conduction distally-first, plotted as a real conduction-velocity-vs-position curve.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted⇄ 3D version
2d-diabetic-neuropathy-nerve-conduction-loss ↗ Open standalone

This simulator renders a single peripheral nerve fibre at length-dependent-neuropathy scale — from the spinal cord to the toe — as a 2D strip of myelinated internodes and nodes of Ranvier, with a live conduction-velocity-vs-position curve beneath it. Two sliders set cumulative hyperglycemic injury (glycemic control and disease duration), an ischemia toggle adds vasa nervorum microvascular damage, and firing an action potential sends a real impulse down the fibre so you can watch saltatory conduction slow through demyelinated segments and block entirely once distal axon loss passes the point degeneration has reached — reproducing, mechanistically, why diabetic neuropathy begins as numbness in the toes rather than the thigh.

⚙ Under the hood

Model a peripheral nerve fibre from spinal cord to toe and watch chronic hyperglycemia and vasa nervorum ischemia drive length-dependent 'dying-back' demyelination, slowing and eventually blocking saltatory conduction distally first.

diabetesneuropathynerve conductiondemyelinationperipheral nervephysiology

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install

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