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Autophagy & Lysosomal Degradation Pathway (2D)

2D autophagy kinetics lab: phagophore nucleation and expansion around damaged cargo, autophagosome closure, transport, lysosome-limited fusion, and acid-hydrolase-driven exponential degradation, all timed by tunable induction, lysosome-count and cargo-size rates.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted⇄ 3D version

This 2D companion turns the 3D scene's autophagy pathway into a readable kinetic model rather than a decorative reskin: damaged cargo (a mitochondrion or a protein aggregate) spawns inside the cell, a phagophore nucleates and expands around it at a rate the induction slider drives directly (falling mTOR / rising AMPK activates ULK1), the closed autophagosome travels to one of a limited pool of lysosomes — queuing visibly when none are free — and, once fused into an autolysosome, degrades on an exponential clearance curve whose time constant scales with cargo size. Raise induction while starving the cell of lysosomes and the fusion bottleneck that real cells face becomes directly visible in the live readout.

⚙ Under the hood

2D autophagy kinetics lab with real per-stage rates: nucleation and phagophore-expansion rate scale with induction (AMPK/ULK1 drive) and cargo size, transport runs at a fixed cytoskeletal speed, fusion is capped by a finite lysosome pool (a queuing bottleneck), and degradation follows an exponential acid-hydrolase clearance curve whose time constant grows with cargo size.

autophagylysosomemtorcell biologyorganelle recyclingautophagosomeacid hydrolases

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install