🫀 High-Intensity Statin Secondary Prevention Simulator

Post-MI Baseline LDL Burden

Placeholder: baseline LDL is high right after an acute coronary event.

• 190 mg/dL: Baseline LDL (Placeholder value)
• <70 mg/dL: Guideline target (Placeholder value)
• Lipid-rich: Plaque core (Placeholder value)
• Thin/fragile: Cap status (Placeholder value)

Why baseline LDL matters

Placeholder: high LDL drives ongoing plaque lipid accumulation.

High-Intensity Statin Initiation

Placeholder: high-intensity statin therapy is started promptly.

• High-intensity: Statin class (Placeholder value)
• Atorva/Rosuva: Typical agents (Placeholder value)
• >50%: Expected LDL drop (Placeholder value)
• At discharge: Start timing (Placeholder value)

Why start high-intensity early

Placeholder: early high-dose therapy maximizes secondary prevention benefit.

LDL Reduction Toward Target

Placeholder: LDL declines sharply toward the guideline-recommended target.

• >50%: Target reduction (Placeholder value)
• ~4-6 wks: Time to effect (Placeholder value)
• <70 mg/dL: LDL at target (Placeholder value)
• Lipid panel: Monitoring (Placeholder value)

Dose-response of LDL lowering

Placeholder: greater LDL lowering associates with greater plaque benefit.

Fibrous Cap Stabilization

Placeholder: sustained LDL lowering thickens and stabilizes the fibrous cap.

• Increasing: Cap thickness (Placeholder value)
• Shrinking: Core size (Placeholder value)
• Decreasing: Inflammation (Placeholder value)
• IVUS/OCT: Imaging tool (Placeholder value)

Plaque regression mechanism

Placeholder: lipid efflux and reduced inflammation stabilize plaque.

Recurrent Event Risk Reduction

Placeholder: stabilized plaque and lower LDL reduce recurrent MI risk.

• ~30-45%: Relative risk ↓ (Placeholder value)
• 2 years: Time horizon (Placeholder value)
• Critical: Adherence (Placeholder value)
• Fewer MACE: Outcome (Placeholder value)

Long-term secondary prevention

Placeholder: durable therapy sustains lower recurrent event risk.

Placeholder: consistent high-intensity statin use is key to lasting benefit.