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CYP450 Pharmacogenomic Dosing Simulator

Interactive pharmacokinetic simulator: pick a patient's CYP450 metabolizer phenotype (poor, intermediate, normal, ultrarapid) and watch how it changes the plasma drug concentration curve, half-life and risk of over- or under-dosing under a real one-compartment PK model.

Genetics & Evolution2DModerate60 FPS📱 Mobile-adapted

Individual genetic variation in drug-metabolizing enzymes is the core mechanism behind personalized medicine dosing. This simulator models a real one-compartment pharmacokinetic system: pick a patient's CYP450 metabolizer phenotype — poor, intermediate, normal or ultrarapid — set the dose and dosing interval, and watch a live 3D plasma-concentration curve unfold against the drug's therapeutic window. Poor metabolizers accumulate the drug toward toxicity; ultrarapid metabolizers clear it before it can work — exactly the risk pre-emptive pharmacogenomic testing is designed to catch before a prescription is written. An orbiting enzyme cluster visualizes the underlying metabolic clearance rate, and live readouts track current concentration, half-life, steady-state average and percentage of time spent inside the safe window.

⚙ Under the hood

This simulation allows users to investigate how individual genetic variations influence a patient's response to medications, showcasing the core principles of pharmacogenomics and its application in personalized medicine. By manipulating simulated gene sequences and drug dosages, you can observe the impact on predicted outcomes and gain insights into tailoring treatments for optimal efficacy.

Personalized MedicinePharmacogenomicsDrug Response

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install