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Chromatin Folding & TAD Loops (2D)

Interactive 2D chromatin fibre: slide histone acetylation to fold nucleosome beads-on-a-string euchromatin into a condensed 30nm heterochromatin zig-zag, then extrude a cohesin loop between two convergent CTCF sites to watch a topologically associating domain (TAD) form.

Genetics & Evolution2DEasy60 FPS📱 Mobile-adapted⇄ 3D version

This 2D canvas simulator draws a chromatin fibre as a chain of nucleosome beads joined by linker-DNA segments. Histone acetylation continuously morphs the fibre between an open "beads-on-a-string" euchromatin state and a compact 30nm-style heterochromatin zig-zag, with real nucleosome repeat lengths and compaction folds tracked live. Switch to TAD-loop mode and extrude a cohesin ring along the fibre — either by hand or with auto-extrude — until it locks between two convergent CTCF anchor sites, the same loop-extrusion mechanism that Hi-C maps reveal as a topologically associating domain in real genomes.

⚙ Under the hood

Fold a 2D chromatin fibre from open beads-on-a-string euchromatin into a condensed heterochromatin zig-zag, then extrude a cohesin loop between two CTCF sites to form a TAD.

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install