Home▸Disease Modeling & Target Validation▸Synthetic Lethality Explorer (2D)

Synthetic Lethality Explorer (2D) — DNA-Repair Gene Network

Interactive 2D genetic-interaction network: knock out pairs of DNA-repair genes and watch a real synthetic-lethality model — the same backup-pathway logic behind PARP inhibitors in BRCA-mutant cancer — compute expected vs. observed fitness live on a pan-and-zoom node graph.

Disease Modeling & Target Validation2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

Details

CategoryDisease Modeling & Target Validation

RenderingCanvas 2D

DifficultyAdvanced

Target FPS60

ControlsPick Gene A and Gene B from dropdowns (or use the seeded BRCA1/PARP1 pair), adjust the genetic-background stringency slider, then click Knock Out Pair to see the two genes dim and their connecting redundancy edge light up, with a Reset Network button to clear the run; drag to pan the node graph and scroll or use the +/- buttons to zoom.

systems biologygeneticsgene networksynthetic lethalitycancer biology2D

Related simulations

Genomic Profiling (ДНК Секвенування)Scraping and analyzing DNA sequences, searching for mutations in tumors.

Protein Folding Dynamics with AlphaFoldA simulation of protein folding into a 3D structure (thermodynamics, AlphaFold style).

Gene Regulatory Network (CRISPR)Graphical interface. The user edits the gene and observes cascading changes in the… ⊞ All 8 in Disease Modeling & Target Validation →

A twelve-gene genetic-interaction network rendered as a flat, pannable node-and-edge graph, split into a homologous-recombination cluster, a base-excision-repair cluster, two core-essential genes, and two unrelated housekeeping genes as a negative control. Pick any two genes, set how stringent the genetic background is, and knock the pair out together: the simulator computes the textbook multiplicative-model expected fitness against an observed fitness shaped by each gene's real position in the redundancy network, then classifies the pair as independent, aggravating, or synthetically lethal. The built-in BRCA1 + PARP1 example reproduces the mechanism behind PARP-inhibitor cancer therapy — losing either DNA-repair pathway alone is survivable, losing both is not.

⚙ Under the hood

An interactive 2D genetic-interaction network of DNA-repair genes: knock out pairs on a pan-and-zoom node graph and watch a real synthetic-lethality model — the backup-pathway logic behind PARP inhibitors in BRCA-mutant cancer — compute expected vs. observed fitness live.

systems biologygeneticsgene networksynthetic lethalitycancer biology2D

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install