🤧 Fever Pathophysiology & Antipyretic Dosing Simulator

Pyrogens Elevate the Hypothalamic Set-Point

Placeholder: pyrogens push the brain thermostat above normal.

• Exo/endogenous: Pyrogen type (Placeholder short caption)
• PGE2: Mediator (Placeholder short caption)
• Preoptic area: Site (Placeholder short caption)
• 1–3°C: Typical shift (Placeholder short caption)

Set-point signaling

Placeholder: pyrogens raise the thermoregulatory target temperature.

Body Temperature Climbs Toward the New Set-Point

Placeholder: temperature rises to match the elevated thermostat.

• Chill/rise: Phase (Placeholder short caption)
• Shivering: Response (Placeholder short caption)
• 2–6 h: Time to peak (Placeholder short caption)
• 38–40°C: Peak range (Placeholder short caption)

Thermogenic response

Placeholder: shivering and vasoconstriction drive temperature upward.

Weight-Based Acetaminophen Dosing Selection

Placeholder: acetaminophen inhibits COX centrally to lower the set-point.

• Central COX: Mechanism (Placeholder short caption)
• 10–15 mg/kg: Dose range (Placeholder short caption)
• ~30–60 min: Onset (Placeholder short caption)
• 4 doses/day: Max daily (Placeholder short caption)

Central antipyretic action

Placeholder: acetaminophen acts mainly within the CNS on prostaglandin synthesis.

Weight-Based Ibuprofen Dosing Selection

Placeholder: ibuprofen inhibits COX both peripherally and centrally.

• Peripheral+central COX: Mechanism (Placeholder short caption)
• 5–10 mg/kg: Dose range (Placeholder short caption)
• ~30–45 min: Onset (Placeholder short caption)
• 3–4 doses/day: Max daily (Placeholder short caption)

Dual-site antipyretic action

Placeholder: ibuprofen reduces prostaglandins at inflamed tissue and hypothalamus.

Temperature Falls as the Set-Point Resets

Placeholder: lowered set-point triggers sweating and heat loss.

• Sweating/vasodilation: Response (Placeholder short caption)
• 0.5–2°C: Reduction (Placeholder short caption)
• 4–8 h: Duration (Placeholder short caption)
• Per interval: Re-dose (Placeholder short caption)

Resolution and re-dosing

Placeholder: temperature falls until effect wanes and next dose is due.

Choosing between agents

Placeholder: dosing interval and mg/kg strength both shape total reduction.

Placeholder highlight: dose and drug choice jointly set reduction magnitude and timing.