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Continuous Biocatalysis

Marrying enzyme catalysis with continuous flow for efficient synthesis.

mysimulator teamUpdated June 2026≈ 3 min read▶ Open the simulation

Immobilization and Reactors

Supports and binding chemistries

Packed-bed, membrane, and CSTR systems

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Performance

Mass transfer, cofactor management, stability, and productivity metrics.

Examples

Example: Continuous Ketone Reduction

Immobilize ketoreductase on suitable support.

Set up packed-bed with cofactor recycle.

Optimize flow and substrate concentration.

Frequently asked questions

How to choose supports?

Match to enzyme properties and process conditions.

Cofactor recycling?

Enzymatic or electrochemical strategies.

Deactivation?

Stabilizers and mild conditions.

Scaling?

Numbering-up and robust reactor design.

Mass transfer limits?

Optimize particle size and flow.

Cleaning?

CIP strategies compatible with enzymes.

Monitoring?

Inline analytics and feedback control.

Safety?

Containment and low-hazard operations.

Costs?

Enzyme loading vs productivity trade-offs.

Documentation?

Report stability curves and turnover numbers.

Try it live

Everything above runs in your browser — open Chemistry Extension Topic 10: Continuous Biocatalysis and change the parameters while it is running. Nothing is installed, nothing is uploaded, the whole model lives in one tab.

▶ Open Chemistry Extension Topic 10: Continuous Biocatalysis simulation