💊 Extended-Release Stimulant Formulation Simulator

Immediate-Release Dosing — Sharp Peaks and Crashes

Placeholder: one dose releases all at once, causing rapid peak and decline.

• ~1.3 h: Time to peak (Placeholder text)
• 2–3: Doses per day (Placeholder text)
• Common: Rebound effect (Placeholder text)
• ~4–5 h: Coverage window (Placeholder text)

Placeholder heading — single-dose spike

Placeholder body text describing immediate-release absorption and elimination kinetics.

Placeholder heading — repeat dosing need

Placeholder body text describing why multiple daily doses are required.

Placeholder highlight: sharp troughs cause symptom rebound between doses.

Extended-Release Formulation — Engineering Gradual Release

Placeholder: drug embedded in osmotic pump or dissolving bead layers.

• OROS pump: Delivery type (Placeholder text)
• Bead capsule: Alt. delivery (Placeholder text)
• 8–12 h: Release window (Placeholder text)
• Laser-drilled: Orifice size (Placeholder text)

Placeholder heading — osmotic pump mechanism

Placeholder body text describing osmotic core pushing drug through a small hole.

Placeholder heading — bead layer alternative

Placeholder body text describing sequential dissolving of coated bead layers.

Placeholder highlight: engineered shells control release rate over hours.

Morning Dose — Fast Onset From the Immediate-Release Portion

Placeholder: an outer immediate-release layer gives quick symptom relief.

• ~1 h: Onset time (Placeholder text)
• ~30%: IR fraction (Placeholder text)
• Once daily: Dosing frequency (Placeholder text)
• Morning: Time of dose (Placeholder text)

Placeholder heading — quick-onset layer

Placeholder body text describing the fast-dissolving outer coating.

Placeholder heading — bridging to sustained phase

Placeholder body text describing handoff from onset to gradual release.

Placeholder highlight: single morning dose starts the whole-day curve.

Gradual Release Phase — Sustaining Blood Levels for Hours

Placeholder: remaining drug releases steadily, keeping levels smooth.

• 8–12 h: Sustained window (Placeholder text)
• Low: Level variability (Placeholder text)
• Osmosis: Release driver (Placeholder text)
• Minimal: Peak-to-trough (Placeholder text)

Placeholder heading — steady-state plateau

Placeholder body text describing near-constant release rate over hours.

Placeholder heading — comparison to IR troughs

Placeholder body text contrasting sustained plateau with IR peak-crash cycle.

Placeholder highlight: smooth plateau avoids sharp mid-day dips.

All-Day Outcome — Smoother Coverage, Less Rebound

Placeholder: extended-release gives all-day coverage from one morning dose.

• ~90%: Symptom coverage (Placeholder text)
• Reduced: Rebound severity (Placeholder text)
• 1: Daily doses needed (Placeholder text)
• High: Level stability (Placeholder text)

Placeholder heading — all-day symptom control

Placeholder body text describing coverage across school or work hours.

Placeholder heading — fewer peaks and troughs

Placeholder body text summarizing benefits versus immediate-release dosing.

Placeholder highlight: one dose, smoother curve, less rebound overall.