Free enzyme site
Occupied / busy site
Drug molecule
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Liver enzymes such as cytochrome P450 have a finite number of active sites available to metabolize a drug at any instant. This simulator models that pool directly: raise the dose slider and watch a fixed cluster of 3D enzyme sites shift from mostly free (low dose) to almost entirely occupied (high dose), while the metabolism-rate curve on the right rises then flattens at its maximum, Vmax, and the concentration-over-time trace shows blood levels settling to a proportional steady state below saturation — or climbing without bound once dose exceeds the enzyme system's maximum clearance capacity.