Home▸Medical Technology & Imaging Physics▸Thyroid Hormone Feedback: The TSH-T3-T4 Axis

🦋 Thyroid Hormone Feedback: The TSH-T3-T4 Axis

Explore how the hypothalamic-pituitary-thyroid axis regulates metabolism through TRH, TSH, T3, and T4, and see how this feedback loop breaks down in hypothyroidism and hyperthyroidism.

Medical Technology & Imaging Physics3DModerate60 FPS

This simulator demonstrates how the hypothalamus, pituitary, and thyroid gland interact through negative feedback to regulate TRH, TSH, T3, and T4 levels, and how this loop shifts in hypothyroidism and hyperthyroidism.

🔬 What It Demonstrates

🎮 How to Use

Adjust the thyroid gland activity or hormone levels using the controls and watch how TRH and TSH respond automatically through the negative feedback loop, then compare the resulting pattern to normal, hypothyroid, and hyperthyroid reference states.

💡 Did You Know?

Did you know the thyroid releases roughly twenty times more T4 than T3, yet T3 is the form that binds most strongly to hormone receptors inside your cells and drives most of thyroid hormone's metabolic effects?

⚙ Under the hood

Explore how the hypothalamic-pituitary-thyroid axis regulates metabolism through TRH, TSH, T3, and T4, and see how this feedback loop breaks down in hypothyroidism and hyperthyroidism.

thyroidendocrinologytshhormonesnegative feedbackhpt axishypothyroidismhyperthyroidism

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install