🧬 Oligonucleotide Chemistry & Modifications

Phosphorothioate Backbone Nuclease ResistanceNewThis simulation focuses on the resistance of nucleic acids to nucleases by substituting… 2'-O-Methyl / MOE Sugar ModificationNewThis simulation illustrates the modification of sugar rings in oligonucleotides to increase… GalNAc Conjugate Hepatocyte TargetingNewThis simulation demonstrates the conjugation of siRNAs with GalNAc to target hepatocytes via… Locked Nucleic Acid (LNA) Gapmer DesignNewThis simulation showcases the design of LNA-gapmer structures to activate RNase H. Users can… siRNA Off-Target Seed Region ScreeningNewThis simulation provides a method for screening the off-target activity of siRNAs by… Antisense Oligonucleotide Tissue DistributionNewThis simulation illustrates the distribution of antisense oligonucleotides in various organs… CRISPR Guide RNA Off-Target PredictionNewThis simulation allows users to predict off-target sites for guide RNA in the genome using… mRNA Nucleoside Modification (Pseudouridine)NewThis simulation demonstrates the process of replacing uridine with pseudouridine in mRNA…