🧬 Oligonucleotide Chemistry & Modifications

Phosphorothioate Backbone Nuclease ResistanceNew📱This simulation focuses on the resistance of nucleic acids to nucleases by substituting… 2'-O-Methyl / MOE Sugar ModificationNew📱This simulation illustrates the modification of sugar rings in oligonucleotides to increase… GalNAc Conjugate Hepatocyte TargetingNew📱This simulation demonstrates the conjugation of siRNAs with GalNAc to target hepatocytes via… Locked Nucleic Acid (LNA) Gapmer DesignNew📱This simulation showcases the design of LNA-gapmer structures to activate RNase H. Users can… siRNA Off-Target Seed Region ScreeningNew📱This simulation provides a method for screening the off-target activity of siRNAs by… Antisense Oligonucleotide Tissue DistributionNew📱This simulation illustrates the distribution of antisense oligonucleotides in various organs… CRISPR Guide RNA Off-Target PredictionNew📱This simulation allows users to predict off-target sites for guide RNA in the genome using… mRNA Nucleoside Modification (Pseudouridine)New📱This simulation demonstrates the process of replacing uridine with pseudouridine in mRNA…