Home▸Medical Technology & Imaging Physics▸Phosphate Homeostasis: The FGF23-Klotho Axis

🦴 Phosphate Homeostasis: The FGF23-Klotho Axis

Explore how the body keeps serum phosphate steady through the classical PTH/vitamin D loop and the more recently discovered FGF23-Klotho hormone axis, and why chronic kidney disease disrupts this balance.

Medical Technology & Imaging Physics3DModerate60 FPS🌍 Earth

This simulator demonstrates how serum phosphate is jointly controlled by the classical PTH-vitamin D loop and the FGF23-Klotho axis, and how both systems respond to changes in dietary phosphate intake and kidney function.

🔬 What It Demonstrates

🎮 How to Use

Adjust dietary phosphate intake and simulated kidney function to see how PTH, active vitamin D, and FGF23 levels shift in response, and observe how serum phosphate is kept stable or drifts out of range as compensation succeeds or fails.

💡 Did You Know?

FGF23 was only identified as a phosphate-regulating hormone in the early 2000s, making it one of the more recently discovered major endocrine hormones, despite phosphate being just as vital to survival as calcium or glucose.

⚙ Under the hood

phosphatefgf23klothovitamin dparathyroid hormonebone metabolismchronic kidney diseasemineral homeostasis

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install