Negative Feedback vs Open-Loop Gene Circuit

Many genes regulate themselves: their own protein product represses further transcription once levels get high enough, creating a self-correcting homeostatic setpoint. This simulator runs two identical gene-expression pipelines side by side — one wired with that negative-feedback loop, one without — and lets you inject the same perturbation into both. Watch the feedback circuit's protein level dip or spike, then snap back toward its target; watch the open-loop circuit take the same hit and simply stay displaced, with nothing pulling it home.