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🧬 B Cell Affinity Maturation: How Antibodies Get Better Over Time

Explore how B cells in germinal centers mutate and compete to produce sharper, tighter-binding antibodies, and why booster shots make your immune response stronger.

Medicine & Biophysics3DModerate60 FPS

This simulation demonstrates how B cells in a germinal center accumulate random mutations and are then selected for antigen-binding affinity across repeated rounds, showing how average antibody quality rises over time.

🔬 What It Demonstrates

🎮 How to Use

Run successive rounds of mutation and selection, watch low-affinity clones get eliminated by simulated apoptosis, and track how the surviving population's average affinity climbs toward the higher end of the 100 to 1000-fold improvement range.

💡 Did You Know?

A single germinal center reaction can cull the large majority of the B cells it produces, meaning most of the antibody variants generated during an infection never make it to become memory cells or plasma cells.

⚙ Under the hood

Explore how B cells in germinal centers mutate and compete to produce sharper, tighter-binding antibodies, and why booster shots make your immune response stronger.

immunologyb cellsantibodiesgerminal centersomatic hypermutationvaccinesaffinity maturationadaptive immunity

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install