Home▸Medical Technology & Imaging Physics▸Leptin and Ghrelin: The Hormones That Balance Hunger and Fullness

⚖️ Leptin and Ghrelin: The Hormones That Balance Hunger and Fullness

Explore how leptin from fat cells and ghrelin from the stomach act as opposing hormonal signals that regulate hunger, satiety, and long-term body weight through the brain's arcuate nucleus.

Medical Technology & Imaging Physics3DModerate60 FPS

This simulator demonstrates how leptin and ghrelin levels shift with fat mass and meal timing, and how the arcuate nucleus integrates these opposing signals into a net hunger or satiety output.

🔬 What It Demonstrates

This simulator demonstrates how leptin and ghrelin levels shift with fat mass and meal timing, and how the arcuate nucleus integrates these opposing signals into a net hunger or satiety output.

🎮 How to Use

Adjust body fat mass and time since last meal to see how leptin and ghrelin levels change, then observe how POMC/CART and AgRP/NPY neuron activity responds, including the effect of simulated leptin resistance.

💡 Did You Know?

Did you know that people who lose significant weight often show a drop in leptin and a rise in ghrelin that can persist for a year or more, which is part of why the body seems to fight to regain lost weight.

⚙ Under the hood

Explore how leptin from fat cells and ghrelin from the stomach act as opposing hormonal signals that regulate hunger, satiety, and long-term body weight through the brain's arcuate nucleus.

leptinghrelinhunger hormonessatietyhypothalamusobesitymetabolismappetite regulation

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install