🧵 Peptide Therapeutics & Cyclic Peptide Design

Solid-Phase Peptide SynthesisNewThis step-by-step simulation of solid-phase peptide synthesis controls the efficiency of… Cyclic Peptide Macrocyclization StrategyNewA method to cyclize linear peptides to enhance proteolytic stability and potentially improve… Stapled Peptide Helix StabilizationNewChemically cross-linking an alpha-helix of a peptide to stabilize its conformation. Peptide Half-Life Extension (PEGylation)NewExtending the half-life of a peptide through PEGylation or lipidation. Cell-Penetrating Peptide DeliveryNewUsing a cell-penetrating peptide to deliver cargo across the cellular membrane. D-Amino Acid Protease Resistance DesignNewDesigning peptide resistance to proteases by replacing L-amino acids with D-amino acids. Peptide-Receptor Binding Affinity MaturationNewDirected evolution of a peptide for increased binding affinity to its receptor. Multivalent Peptide Dendrimer DisplayNewThis simulation demonstrates the multivalent presentation of peptides on a dendrimer…