Every cell in your body keeps time. A molecular negative-feedback loop — CLOCK, BMAL1, PER — ticks with a 24-hour period set before multicellular life existed.
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Circadian clocks, biological rhythms, and oscillating gene networks
Chronobiology simulations model the molecular and physiological oscillators that govern the daily timing of life. Circadian clock models simulate the transcription-translation feedback loop of clock genes (CLOCK, BMAL1, PER, CRY) as a system of coupled ordinary differential equations, reproducing the ~24 h period and how it entrains to light-dark cycles. Ultradian rhythm simulations model ultradian pulse generators for hormone secretion and sleep-stage cycling.
Phase-resetting curve simulations compute how light pulses of different timing shift the circadian phase — the mathematical basis of jet-lag recovery and shift-work scheduling strategies. Population models show the Kuramoto synchronisation of coupled cellular oscillators, explaining how a molecular clock in each cell drives organ-level rhythms. These models connect biochemistry to physiology and are used in chronopharmacology and sleep-medicine research.
Each simulation in this category is built with accuracy and interactivity in mind. The underlying mathematical models are the same ones used in academic research and professional engineering — just made accessible through a web browser. Changing parameters in real time and observing the results is one of the most effective ways to build intuition for complex scientific and engineering concepts.
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