Home▸Medicine & Biophysics▸Amyloid-Beta Aggregation Kinetics Simulator

🧠 Amyloid-Beta Aggregation Kinetics Simulator

Explore the nucleation-elongation model of amyloid-beta monomers assembling into oligomers and fibrils, and see how monomer concentration or a chaperone inhibitor shifts the sigmoidal aggregation-time curve.

Medicine & Biophysics3DModerate60 FPS

The simulation shows amyloid-beta monomers nucleating and elongating into oligomers and fibrils, producing a sigmoidal aggregation-versus-time curve that shifts when you change monomer concentration or add a chaperone inhibitor.

🔬 What It Demonstrates

🎮 How to Use

Adjust the monomer concentration slider and toggle a chaperone molecule on or off to see the lag phase lengthen or shorten and the aggregation curve reshape in the live plot.

💡 Did You Know?

The amyloid-beta 42 peptide has just two extra amino acids compared to the more common amyloid-beta 40 form, yet those two residues make it dramatically more prone to aggregating into plaques.

⚙ Under the hood

neuroscienceamyloid betaprotein aggregationalzheimers diseasenucleation kineticsbiophysicsmolecular biologyneurodegeneration

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install