🎯 Zaawansowane metody i dostarczanie docelowo skierowane

PROTAC / Targeted Protein DegradationNewA ternary complex (ligand-linker-E3 ligase) that ubiquitinates the target protein, leading… Antibody-Drug Conjugate (ADC) Payload ReleaseNewInternalization of the ADC by a tumor cell, cleavage of the linker in the lysosome, release… Allosteric Modulator BindingNewBinding of a ligand to a site other than the active center of a protein, resulting in… mRNA Circular / Self-Amplifying DesignNewOptimization of UTR sequences, codon optimization, stability of the cap and poly-A tail,… Molecular Glue DegraderNewAn induced 'gluing' of two proteins without a linker (e.g., IMiDs), creating a new…