UGT Glucuronidation

Phase II conjugation pathway — UDP-glucuronosyltransferases inactivating and solubilizing xenobiotics for biliary and renal elimination

Current Stage

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Substrate Bound

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Catalytic Rate

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Conjugate Efflux

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Systemic Clearance

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SubstrateBilirubin

UGT1A1 Genotype*1/*1 (wild-type)

Xenobiotic substrate molecule

UGT active site / UDPGA donor

Glucuronide conjugate

MRP2/MRP3 efflux transporter

Renal / biliary elimination