Pharmacokinetics Lab

Pharmacokinetics lab (ADME)

Plasma concentration0

Effect (Emax model)0%

Window status-

Peak (Cmax at Tmax)-

Terminal half-life-

Accumulation / Css-

AUC so far0

Time0 h

Drugs

Controls

Saturable (Michaelis-Menten) metabolism

Where is the drug?

Click the gut (or the pill), drag the liver and kidney handles to change enzyme activity and renal function. Hover any organ for its amount.

Model: oral dosing into a gut depot (first-order absorption k_a, bioavailability F), a two-compartment body (central V1, peripheral V2, exchange k12 and k21), hepatic metabolism (linear or Michaelis-Menten) and renal excretion, solved by RK4. Effect: E = Emax Cⁿ/(EC50ⁿ + Cⁿ) on the unbound concentration. Parameters are rounded textbook values for a 70 kg adult (Rowland and Tozer; Goodman and Gilman); illustrative only, not dosing advice.