💊 Pharmacokinetics

Drug preset

Route of administration Dose (mg): 500 V_d — volume of distribution (L): 30 k_e — elimination rate (h⁻¹): 0.12 k_a — absorption rate (h⁻¹): 1.2 F — bioavailability (%): 80

Log scale Y-axis

C_max—

t_max—

t_½ half-life—

AUC₀₋∞—

Clearance (L/h)—

One-compartment PK model
IV: C(t) = C₀·e^−ke·t
Oral: C(t) = F·D·Ka / (Vd·(Ka−Ke)) · (e^−Ke·t − e^−Ka·t)
t½ = 0.693 / ke · Clearance = Vd·ke