This simulation demonstrates how the end-replication problem causes telomeres to shorten with successive cell divisions, and how telomerase activity can counteract that shortening to delay or prevent the Hayflick limit.
Adjust the division rate and telomerase activity level to watch telomere length change over successive divisions, and observe when the cell reaches senescence under different conditions.
Sliders let you control cell division speed and telomerase activity, while a live readout tracks telomere length and cell state across generations.
Leonard Hayflick's discovery that cells have a finite division limit overturned the long-held belief that cells cultured outside the body could divide forever, reshaping how scientists understand aging at the cellular level.
This simulation demonstrates how the end-replication problem causes telomeres to shorten with successive cell divisions, and how telomerase activity can counteract that shortening to delay or prevent the Hayflick limit.
This simulation demonstrates how the end-replication problem causes telomeres to shorten with successive cell divisions, and how telomerase activity can counteract that shortening to delay or prevent the Hayflick limit.
Adjust the division rate and telomerase activity level to watch telomere length change over successive divisions, and observe when the cell reaches senescence under different conditions.
Leonard Hayflick's discovery that cells have a finite division limit overturned the long-held belief that cells cultured outside the body could divide forever, reshaping how scientists understand aging at the cellular level.