Lipid Peroxidation Biomarkers

From membrane PUFA attack to clinical signal — MDA, F2-isoprostanes and 4-HNE as quantitative readouts of oxidative tissue damage

Current Stage

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Plasma MDA

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F2-IsoP (iPF2α-III)

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4-HNE adducts

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Assay QC

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Oxidative Stress Flux (ROS)Moderate

Antioxidant Reserve (GSH/Vit E)Normal

Intact PUFA phospholipid tail

Peroxyl / alkoxyl radical (propagating)

Malondialdehyde (MDA) fragment

F2-isoprostane (from arachidonic acid)

4-HNE — protein/DNA adduct former