D2 Occupancy Window
2D synapse model · the 65–80% therapeutic band of D2 receptor blockade by antipsychotics
Status
—
Efficacy
—
EPS risk
—
Dose action
—
Estimated D2 occupancy
70%
Patient sensitivity profile
Standard
Standard
Higher sensitivity (older adult / prior EPS)
Drug release rate
Normal
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Dopamine molecule
Antipsychotic molecule
Blocked D2 receptor
Open D2 receptor
Occupancy vs. efficacy / EPS
Drag the occupancy slider — watch receptors fill and the risk curves respond