This simulator demonstrates how the hypothalamus, pituitary, and thyroid gland interact through negative feedback to regulate TRH, TSH, T3, and T4 levels, and how this loop shifts in hypothyroidism and hyperthyroidism.
Adjust the thyroid gland activity or hormone levels using the controls and watch how TRH and TSH respond automatically through the negative feedback loop, then compare the resulting pattern to normal, hypothyroid, and hyperthyroid reference states.
Sliders let you adjust thyroid gland output and simulate clinical states, instantly updating TRH, TSH, T3, and T4 levels across the feedback loop.
Did you know the thyroid releases roughly twenty times more T4 than T3, yet T3 is the form that binds most strongly to hormone receptors inside your cells and drives most of thyroid hormone's metabolic effects?
This simulator demonstrates how the hypothalamus, pituitary, and thyroid gland interact through negative feedback to regulate TRH, TSH, T3, and T4 levels, and how this loop shifts in hypothyroidism and hyperthyroidism.
This simulator demonstrates how the hypothalamus, pituitary, and thyroid gland interact through negative feedback to regulate TRH, TSH, T3, and T4 levels, and how this loop shifts in hypothyroidism and hyperthyroidism.
Adjust the thyroid gland activity or hormone levels using the controls and watch how TRH and TSH respond automatically through the negative feedback loop, then compare the resulting pattern to normal, hypothyroid, and hyperthyroid reference states.
Did you know the thyroid releases roughly twenty times more T4 than T3, yet T3 is the form that binds most strongly to hormone receptors inside your cells and drives most of thyroid hormone's metabolic effects?