This simulator demonstrates how serum phosphate is jointly controlled by the classical PTH-vitamin D loop and the FGF23-Klotho axis, and how both systems respond to changes in dietary phosphate intake and kidney function.
Adjust dietary phosphate intake and simulated kidney function to see how PTH, active vitamin D, and FGF23 levels shift in response, and observe how serum phosphate is kept stable or drifts out of range as compensation succeeds or fails.
Sliders let you vary dietary phosphate intake and kidney function while the simulator displays the resulting PTH, active vitamin D, FGF23, and serum phosphate levels in real time.
FGF23 was only identified as a phosphate-regulating hormone in the early 2000s, making it one of the more recently discovered major endocrine hormones, despite phosphate being just as vital to survival as calcium or glucose.
This simulator demonstrates how serum phosphate is jointly controlled by the classical PTH-vitamin D loop and the FGF23-Klotho axis, and how both systems respond to changes in dietary phosphate intake and kidney function.
This simulator demonstrates how serum phosphate is jointly controlled by the classical PTH-vitamin D loop and the FGF23-Klotho axis, and how both systems respond to changes in dietary phosphate intake and kidney function.
Adjust dietary phosphate intake and simulated kidney function to see how PTH, active vitamin D, and FGF23 levels shift in response, and observe how serum phosphate is kept stable or drifts out of range as compensation succeeds or fails.
FGF23 was only identified as a phosphate-regulating hormone in the early 2000s, making it one of the more recently discovered major endocrine hormones, despite phosphate being just as vital to survival as calcium or glucose.