This simulator demonstrates how pulsatile GnRH, FSH, LH, estrogen, and progesterone interact across a 28-day cycle, including the pivotal moment when rising estrogen flips the hypothalamic-pituitary feedback from negative to positive.
Step through or scrub across the cycle day by day to watch each hormone curve rise and fall, and observe how the feedback mode indicator switches from negative to positive right before the LH surge and ovulation.
Use the day slider or play button to move through the 28-day cycle and watch GnRH pulses, FSH, LH, estrogen, and progesterone respond in real time.
Did you know that the same estrogen molecule can either suppress or stimulate the exact same brain cells, purely depending on how high its concentration climbs and how long it stays there?
This simulator demonstrates how pulsatile GnRH, FSH, LH, estrogen, and progesterone interact across a 28-day cycle, including the pivotal moment when rising estrogen flips the hypothalamic-pituitary feedback from negative to positive.
This simulator demonstrates how pulsatile GnRH, FSH, LH, estrogen, and progesterone interact across a 28-day cycle, including the pivotal moment when rising estrogen flips the hypothalamic-pituitary feedback from negative to positive.
Step through or scrub across the cycle day by day to watch each hormone curve rise and fall, and observe how the feedback mode indicator switches from negative to positive right before the LH surge and ovulation.
Did you know that the same estrogen molecule can either suppress or stimulate the exact same brain cells, purely depending on how high its concentration climbs and how long it stays there?