This simulator demonstrates how leptin and ghrelin levels shift with fat mass and meal timing, and how the arcuate nucleus integrates these opposing signals into a net hunger or satiety output.
Adjust body fat mass and time since last meal to see how leptin and ghrelin levels change, then observe how POMC/CART and AgRP/NPY neuron activity responds, including the effect of simulated leptin resistance.
Sliders control body fat mass, time since last meal, and a leptin resistance toggle, dynamically updating hormone levels and hypothalamic neuron activity.
Did you know that people who lose significant weight often show a drop in leptin and a rise in ghrelin that can persist for a year or more, which is part of why the body seems to fight to regain lost weight.
This simulator demonstrates how leptin and ghrelin levels shift with fat mass and meal timing, and how the arcuate nucleus integrates these opposing signals into a net hunger or satiety output.
This simulator demonstrates how leptin and ghrelin levels shift with fat mass and meal timing, and how the arcuate nucleus integrates these opposing signals into a net hunger or satiety output.
Adjust body fat mass and time since last meal to see how leptin and ghrelin levels change, then observe how POMC/CART and AgRP/NPY neuron activity responds, including the effect of simulated leptin resistance.
Did you know that people who lose significant weight often show a drop in leptin and a rise in ghrelin that can persist for a year or more, which is part of why the body seems to fight to regain lost weight.