This simulator demonstrates how blood from the digestive organs is rerouted through the liver via the hepatic portal vein before reaching systemic circulation, and how that detour causes first-pass metabolism to reduce the effective dose of an orally administered drug.
Choose a route of administration, such as oral, sublingual, or injection, and adjust the drug dose to watch how much of it survives the liver's first pass and reaches systemic blood levels.
Sliders and route toggles let you adjust the administered dose and choose between oral, sublingual, transdermal, and injected delivery to see the resulting systemic blood concentration.
Grapefruit juice can inhibit some of the liver's first-pass metabolizing enzymes, which is why it can dangerously increase blood levels of certain oral medications.
This simulator demonstrates how blood from the digestive organs is rerouted through the liver via the hepatic portal vein before reaching systemic circulation, and how that detour causes first-pass metabolism to reduce the effective dose of an orally administered drug.
This simulator demonstrates how blood from the digestive organs is rerouted through the liver via the hepatic portal vein before reaching systemic circulation, and how that detour causes first-pass metabolism to reduce the effective dose of an orally administered drug.
Choose a route of administration, such as oral, sublingual, or injection, and adjust the drug dose to watch how much of it survives the liver's first pass and reaches systemic blood levels.
Grapefruit juice can inhibit some of the liver's first-pass metabolizing enzymes, which is why it can dangerously increase blood levels of certain oral medications.