The simulation shows how falling tissue oxygen stabilizes HIF in kidney sensing cells, drives a rise in erythropoietin release, and triggers new red blood cell production that gradually restores oxygen delivery and shuts the signal back off.
Adjust the ambient or blood oxygen level and watch HIF accumulation, erythropoietin secretion, and bone marrow red blood cell output respond and interact in real time across a simulated multi-day timeline.
Sliders let you set blood or ambient oxygen level, simulated altitude, and elapsed time, while toggles can simulate chronic kidney disease damage or exogenous erythropoietin administration to see how each factor shifts the feedback loop.
The enzymes that tag HIF for destruction use oxygen directly as a chemical reactant, meaning the cell's oxygen sensor is not a separate detector molecule but the very chemistry of an enzyme running out of its own ingredient.
The simulation shows how falling tissue oxygen stabilizes HIF in kidney sensing cells, drives a rise in erythropoietin release, and triggers new red blood cell production that gradually restores oxygen delivery and shuts the signal back off.
The simulation shows how falling tissue oxygen stabilizes HIF in kidney sensing cells, drives a rise in erythropoietin release, and triggers new red blood cell production that gradually restores oxygen delivery and shuts the signal back off.
Adjust the ambient or blood oxygen level and watch HIF accumulation, erythropoietin secretion, and bone marrow red blood cell output respond and interact in real time across a simulated multi-day timeline.
The enzymes that tag HIF for destruction use oxygen directly as a chemical reactant, meaning the cell's oxygen sensor is not a separate detector molecule but the very chemistry of an enzyme running out of its own ingredient.