outside air ↑stratum corneumdermis (moist) ↓
Water molecule (TEWL) Irritant / allergen Corneocyte "brick" Intact lipid "mortar"
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Skin Barrier: Lipid Mortar Integrity Lab

The stratum corneum blocks water loss and outside irritants at the same time, using one structure: flattened corneocyte "bricks" sealed together by a layered lipid "mortar." This model erodes that mortar as you drag barrier integrity down, so you can watch water escape faster (rising TEWL) and irritant particles start punching through the same widening gaps, live.