The simulator demonstrates the dynamic push-and-pull between tissue insulin sensitivity and beta cell insulin output, showing how their opposing changes keep blood glucose stable for a period of time, how HOMA-IR reveals the hidden strain in that balance, and how blood glucose finally rises once beta cell compensation can no longer keep up with worsening resistance.
Adjust the tissue insulin sensitivity slider downward to simulate worsening insulin resistance, and watch the beta cell output rise automatically to compensate while blood glucose stays flat. Then reduce the beta cell secretory capacity slider to simulate beta cell fatigue and observe how blood glucose and HOMA-IR respond once compensation can no longer keep pace, tracking the shift from normal through prediabetes toward diabetic range.
Sliders control tissue insulin sensitivity and beta cell secretory capacity independently; readouts display fasting glucose, fasting insulin, and calculated HOMA-IR updating in real time as the two variables interact.
Did you know that by the time fasting glucose crosses into the prediabetic range, tissue insulin sensitivity has often already been declining for many years, quietly hidden behind rising insulin output that a standard glucose-only blood test would never reveal?
The simulator demonstrates the dynamic push-and-pull between tissue insulin sensitivity and beta cell insulin output, showing how their opposing changes keep blood glucose stable for a period of time, how HOMA-IR reveals the hidden strain in that balance, and how blood glucose finally rises once beta cell compensation can no longer keep up with worsening resistance.
The simulator demonstrates the dynamic push-and-pull between tissue insulin sensitivity and beta cell insulin output, showing how their opposing changes keep blood glucose stable for a period of time, how HOMA-IR reveals the hidden strain in that balance, and how blood glucose finally rises once beta cell compensation can no longer keep up with worsening resistance.
Adjust the tissue insulin sensitivity slider downward to simulate worsening insulin resistance, and watch the beta cell output rise automatically to compensate while blood glucose stays flat. Then reduce the beta cell secretory capacity slider to simulate beta cell fatigue and observe how blood glucose and HOMA-IR respond once compensation can no longer keep pace, tracking the shift from normal through prediabetes toward diabetic range.
Did you know that by the time fasting glucose crosses into the prediabetic range, tissue insulin sensitivity has often already been declining for many years, quietly hidden behind rising insulin output that a standard glucose-only blood test would never reveal?