The simulation shows a population of proteins destabilizing under rising temperature while Hsp70 and Hsp90 chaperones bind exposed hydrophobic patches to prevent aggregation, until chaperone demand exceeds available supply.
Raise the temperature slider to increase thermal stress and watch chaperones intervene in real time, and adjust the chaperone supply slider to see how much stress the system can absorb before aggregates begin forming.
Temperature slider and a chaperone supply slider
Heat-shock proteins were discovered by accident in 1962 when a researcher accidentally overheated an incubator holding fruit fly larvae and noticed dramatic new patterns appear in their chromosomes.
The simulation shows a population of proteins destabilizing under rising temperature while Hsp70 and Hsp90 chaperones bind exposed hydrophobic patches to prevent aggregation, until chaperone demand exceeds available supply.
The simulation shows a population of proteins destabilizing under rising temperature while Hsp70 and Hsp90 chaperones bind exposed hydrophobic patches to prevent aggregation, until chaperone demand exceeds available supply.
Raise the temperature slider to increase thermal stress and watch chaperones intervene in real time, and adjust the chaperone supply slider to see how much stress the system can absorb before aggregates begin forming.
Heat-shock proteins were discovered by accident in 1962 when a researcher accidentally overheated an incubator holding fruit fly larvae and noticed dramatic new patterns appear in their chromosomes.