The simulation shows a liver enzyme pool metabolizing a drug over time, then lets you introduce a competing molecule as an inhibitor or inducer to see how the plasma concentration curve shifts toward toxicity or subtherapeutic failure.
Adjust the drug dose slider and select an interacting molecule to add as an inhibitor or inducer, then watch the plasma concentration curve update in real time along with a toxicity and efficacy threshold overlay.
Sliders for drug dose and enzyme activity, plus a toggle to add an inhibitor or inducer molecule
CYP3A4, a single enzyme isoform, is estimated to metabolize roughly half of all clinically prescribed medications in use today.
The simulation shows a liver enzyme pool metabolizing a drug over time, then lets you introduce a competing molecule as an inhibitor or inducer to see how the plasma concentration curve shifts toward toxicity or subtherapeutic failure.
The simulation shows a liver enzyme pool metabolizing a drug over time, then lets you introduce a competing molecule as an inhibitor or inducer to see how the plasma concentration curve shifts toward toxicity or subtherapeutic failure.
Adjust the drug dose slider and select an interacting molecule to add as an inhibitor or inducer, then watch the plasma concentration curve update in real time along with a toxicity and efficacy threshold overlay.
CYP3A4, a single enzyme isoform, is estimated to metabolize roughly half of all clinically prescribed medications in use today.