3D Glycocalyx Barrier Simulator

Glycocalyx Barrier (3D)

Grafted glycan brush over a lipid membrane. Nanoparticles fall through the mesh under real steric-exclusion and electrostatic physics.

Nanoparticle diameter40 nm

Glycocalyx integrity100%

NP surface charge (zeta)-15 mV

Brush height L

—

Mesh size ξ

—

ΔF / kT

—

D_eff / D_free

—

Penetrated 0 Excluded 0 Trapped 0

Membrane-anchored mucin

Heparan sulfate proteoglycan

Sialylated glycolipid cap (−)

Excluded nanoparticle

Penetrated nanoparticle

Electrostatically trapped