Enzymatic remodeling of ABO glycan antigens over the whole erythrocyte membrane — glycosidases orbit the cell and strip terminal sugars to unmask the universal H antigen.
Antigen conversion
0%
Enzyme dose
0.0 mg/mL
Residual antigen /cell
1.0×10⁶
Reaction time
0 s
Conversion vs. enzyme dose (dose-response sigmoid)
H antigen (universal, exposed)
A antigen (terminal GalNAc)
B antigen (terminal Gal)
Glycosidase enzyme
Cleaved free monosaccharide
Drag — orbit camera · Scroll — zoom · Sliders adjust the reaction live