Toxic Body Burden: Multi-Route Toxicokinetics Simulator

Exposure Route

Exposure Parameters

Dose rate 10 µg/day

Lipophilicity (log K_ow) 4.0

Simulation speed 10 d/s

Live Readouts

Elapsed time

0.0 d

Blood conc.

0.00 µg/L

Body burden (fat)

0.00 µg

Elim. half-life

— d

How it works

A two-compartment first-order toxicokinetic model tracks a xenobiotic entering the body, distributing into blood and fatty tissue, and leaving through hepatic/renal clearance:

dC_b/dt = k_a·D(t) − (k_e + k_p)·C_b + k_r·C_f·(V_f/V_b)
dC_f/dt = k_p·C_b·(V_b/V_f) − k_r·C_f

C_b, C_f = blood / fat concentrations; D(t) = absorbed dose rate; k_a = route-dependent absorption fraction; k_e = hepatic/renal elimination rate from blood; k_p, k_r = partition (blood→fat) and release (fat→blood) rate constants, whose ratio k_p/k_r is set by the lipophilicity slider via a log K_ow-scaled partition coefficient — a more lipophilic toxicant partitions harder into fat and releases more slowly, exactly the mechanism behind bioaccumulation of persistent organic pollutants.

Exposure route — inhalation and ingestion absorb quickly into blood (high k_a); dermal absorption is slower and route-limited (low k_a), matching real toxicokinetic absorption fractions.
Dose rate — continuous daily intake D(t), shown as toxicant particles streaming in from the environment.
Lipophilicity — controls how strongly the toxicant sequesters in the fat compartment instead of being cleared; the half-life readout is the fat compartment's dominant elimination half-life, t½ = ln(2)/k_r.

Real-world relevance: this is the same compartmental logic environmental toxicologists use to model PCBs, dioxins, PFAS and other persistent lipophilic pollutants accumulating in human and wildlife tissue over chronic exposure.

Environment source Blood compartment Fat compartment (body burden)

⚠ Couldn't load the 3D engineThree.js failed to load from the CDN. Check your connection and reload.