GLP-1 Agonist Weight Loss (2D)

How semaglutide & tirzepatide hijack the incretin system to slow gastric emptying, quiet hypothalamic hunger circuits, and drive sustained fat loss

Current stage

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Body weight Δ

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Gastric emptying

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Satiety signal

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Daily intake

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GLP-1 drug dose (titration)0.25 mg

Baseline appetite driveModerate

Native GLP-1 (L-cell, t½ ~2 min)

Exogenous GLP-1R agonist

Activated GLP-1 receptor

Food bolus in GI tract

Hypothalamic hunger neuron