The Skin Lipid Bilayer — Bricks and Mortar
Corneocytes act as bricks held together by a lipid mortar matrix.
- ~50%: Ceramide share (placeholder value)
- ~25%: Cholesterol share (placeholder value)
- ~15%: Free fatty acids (placeholder value)
- 15–20: Barrier layers (placeholder value)
Stratum corneum lipid organization
Placeholder text on lamellar lipid bilayer structure.
Occlusives, Emollients, and Humectants
Different agents seal, smooth, or hydrate the barrier.
- ~30%: Occlusive TEWL cut (placeholder value)
- Glycerin: Humectant type (placeholder value)
- Gaps: Emollient fill (placeholder value)
- ~1 hr: Onset time (placeholder value)
Mechanism classes of moisturizers
Placeholder text on occlusive, humectant, emollient roles.
Frequency of Application Drives Barrier Rebuild
Repeated daily use accelerates lipid matrix restoration.
- 2–3×/day: Optimal frequency (placeholder value)
- ~2×: Rebuild speedup (placeholder value)
- Transient: Single use effect (placeholder value)
- Slows repair: Missed doses (placeholder value)
Dose-frequency relationship
Placeholder text on frequency versus repair rate.
Consistency Lowers Flare-Up Frequency
Weeks of steady use reduce eczema/dermatitis flares.
- ~40%: 8-week flare cut (placeholder value)
- ~60%: 12-week flare cut (placeholder value)
- Strong: Adherence effect (placeholder value)
- Common: Relapse on stop (placeholder value)
Long-term consistency benefit
Placeholder text on flare reduction over weeks.
Long-Term Maintenance Therapy
Reduced-frequency upkeep sustains restored barrier.
- 1–2×/day: Maintenance freq (placeholder value)
- 2×/week: Proactive therapy (placeholder value)
- ~50%: Relapse risk cut (placeholder value)
- Ongoing: Recommended horizon (placeholder value)
Sustaining barrier health
Placeholder text on long-term maintenance regimen.
Placeholder callout: consistent low-dose maintenance prevents relapse.