Erythema Migrans & Lyme Staging

Tick bite to late-stage Lyme disease — untreated progression across five clinical stages.

Current Stage

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EM rash size

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Dissemination

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Joint risk

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Neuro risk

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Days since tick bite0

Treatment statusUntreated

Tick bite site

Erythema migrans (bullseye)

Borrelia spirochetes

Bloodstream dissemination

Joint involvement

CNS involvement

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Tick Attachment and Borrelia Inoculation

Placeholder: infection begins with a tick bite delivering spirochetes.

Ixodes: Vector (Placeholder short note)
36–48h: Attach time (Placeholder short note)
B. burgdorferi: Pathogen (Placeholder short note)
Local skin: Bite site (Placeholder short note)

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Early Localized Erythema Migrans

Placeholder: the classic expanding bullseye rash develops.

3–14 days: Onset (Placeholder short note)
2–3 cm/day: Rash growth (Placeholder short note)
Bullseye: Shape (Placeholder short note)
~70–80%: Frequency (Placeholder short note)

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Placeholder short paragraph about EM rash formation.

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Hematogenous Dissemination of Spirochetes

Placeholder: spirochetes spread via blood to distant tissues.

Days–weeks: Window (Placeholder short note)
Bloodstream: Route (Placeholder short note)
Skin, joints, CNS: Targets (Placeholder short note)
PCR/culture: Detectability (Placeholder short note)

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Placeholder short paragraph about dissemination.

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Early Disseminated Lyme — Multiple EM and Neuro Signs

Placeholder: secondary rashes and early neurologic symptoms emerge.

3–10 weeks: Timing (Placeholder short note)
Multiple sites: Secondary EM (Placeholder short note)
Facial palsy: Neuro signs (Placeholder short note)
AV block: Cardiac risk (Placeholder short note)

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Placeholder short paragraph about early disseminated stage.

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Late-Stage Lyme — Joint and CNS Involvement

Placeholder: untreated disease progresses to arthritis and neuroborreliosis.

Months: Onset (Placeholder short note)
Large joints: Arthritis (Placeholder short note)
Encephalopathy: CNS (Placeholder short note)
Partial: Reversibility (Placeholder short note)

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Placeholder short paragraph about late-stage involvement.

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