Mechanical Load
Remodeling
DISUSE MODE — mechanical unloading active, osteoclasts dominate
Statistics
—
Bone Volume Fraction
—
Trajectory Alignment
—
Osteoblast Activity
—
Osteoclast Activity
0.0 wk
Simulated Time
—
Active Struts
Osteoblast-dominant (forming)
Osteoclast-dominant (resorbing)
Homeostatic (stable)
Wolff's law / bone functional adaptation:
Osteocytes buried in the matrix sense strain via canalicular fluid flow and signal osteoclasts (resorb) and osteoblasts (form) — the coupled remodeling cycle. Trabeculae thicken and reorient along principal stress trajectories under load, and thin/vanish under disuse.
Drag to orbit, scroll to zoom.
Osteocytes buried in the matrix sense strain via canalicular fluid flow and signal osteoclasts (resorb) and osteoblasts (form) — the coupled remodeling cycle. Trabeculae thicken and reorient along principal stress trajectories under load, and thin/vanish under disuse.
Drag to orbit, scroll to zoom.