Aminoglycoside EI Dosing 3D

Extended-interval ("once-daily") dosing: one big peak (cyan, front lane) versus the same daily dose split q8h (blue, middle lane), and the bacterial burden each leaves behind (back lane).

Scenarios

Patient and drug

Est. creatinine clearance

Daily dose target

MIC of the organism

Post-antibiotic effect

Simulation speed

Show PAE zones Show drug-free trough windows (below 1 mg/L)

Run

Dosing result

Dosing interval-

Once-daily dose-

Nomogram status-

Nephrotoxicity risk-

Peak / MIC (EI)-

Peak / MIC (q8h)-

Trough (EI)-

Drug-free h/day-

Time above MIC (EI)-

AUC 24 h (EI)-

At the cursor

Time-

Level EI / q8h-

Burden EI (log CFU)-

Burden q8h (log CFU)-

Serum concentration (sqrt scale)

extended interval q8h split MIC