PROTAC Degrader

Ternary complex (Target–PROTAC–E3 ligase) formation, ubiquitin transfer & proteasomal degradation — quantitative hook-effect model

E3 Ligase Recruiter

Live Metrics

Ternary Complex

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Degradation Dmax

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DC₅₀

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Deg. @ Dose

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Zone Status

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Parameters

PROTAC Dose (D)—

Linker Length (atoms)—

Target Binder Kd—

E3 Ligase Binder Kd—

Cooperativity (α)—

Target protein (POI)

E3 ubiquitin ligase

PROTAC bifunctional linker

Ubiquitin chain (K48)

26S Proteasome

Degradation vs. Dose (Hook Effect)—