ACTH & Cortisol Loop
Using ACTH to localize Cushing's syndrome: adrenal, pituitary, or ectopic source
Current Stage
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ACTH (pg/mL)
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Cortisol (µg/dL)
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Source
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Feedback Loop
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Source Category
Normal
Disease Severity
Mild
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Hypothalamus (CRH)
Pituitary (ACTH)
Adrenal (cortisol)
Ectopic tumor source
Intact negative feedback
Resistant / bypassed loop
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